Suvorexant: The Perfect Hypnotic?

In the issue of Science Translational Medicine published on April 3, 2013, Uslaner et al.  of the American pharmaceutical company Merck report on a new class of hypnotics, which are characterized by a completely new mechanism of action (Uslaner et al., Sci Transl Med 2013). It is called DORA (dual orexin receptor antagonists). In an editorial in the issue of Science published on April 5, 2013, Emmanuel Mignot of Stanford University in California asks the question whether a DORA could be “The Perfect Hypnotic?” (Mignot, Science 2013). Continue reading

Antipsychotics: What Comes Next?

In my post of March 6, 2013, I discussed the approval of the first inhaled antipsychotic (Adasuve – Staccato loxapine), which is expected to be available in a few months. In the next few years, new antipsychotics and new pharmaceutical formulations of already approved substances can be expected to reach the market that will enrich the available armamentarium . These compounds I want to briefly introduce here. Continue reading

Naltrexone and Nalmefene for Alcohol Dependence: Any Meaningful Difference?

In my post of March 17, 2013, I reported that the European Medicines Agency EMA recently approved the long-acting opioid antagonist nalmefene for the treatment of alcohol dependence. In the current issue of Biological Psychiatry now Karl Mann from the Central Institute of Mental Health in Mannheim, Germany, and colleagues report in a “Priority Communication” on the results of the largest  study to date of nalmefene in patients with alcohol dependence (Mann et al.,  2013). Continue reading

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Drug Prescription Report 2012: Antipsychotics

I have not yet covered the antipsychotics in my reporting on the drug prescription report, I want to catch this today. This important group of drugs is discussed in the chapter “psychotropic drugs”. As mentioned already in my post from November 9th, 2012, the quality of the chapter suffers greatly from the superficial and unscientific representation of the two authors Lohse and Müller-Oerlinghausen. I will essentially limit this post on the discussion of the numbers rather than discuss the limitations of the chapter again. Continue reading