Reports from the 51. ACNP Congress — II. Is Ketamine Effective in Obsessive-Compulsive Disorder?

At the 51st Congress of the American College of Neuropsychopharmacology (ACNP), 2nd – 6th December 2012 in Hollywood, Florida, Carolyn I. Rodriguez and colleagues  from Columbia University in New York reported yesterday the results of a small pilot study on the use of ketamine in obsessive-compulsive disorder (OCD). The very rapid antidepressant effects of the NMDA receptor antagonist ketamine in depressive disorders – especially in treatment-resistant patients – has been shown in numerous studies. This applies to both uni- and bipolar depression. A small open case series recently presented also suggests an effect of ketamine in OCD. Continue reading